Personalize dietary and nutritional supplementation based on your genetic profile
The Methyl Detox Profile tests critical genes in the methylation pathway. The methylation pathway is the major part of detoxification and the metabolic cycle. More than 50% of people are affected by genetic variations in the methylation pathway.1-3 This profile enables you to intelligently use nutritional supplementation based on your genetics. The Methyl Detox Profile gives comprehensive insights into the functional status of 3 major genes associated with the methionine/homocysteine cycle.
Go beyond standard MTHFR genotyping
Standard MTHFR genotyping only evaluates folic acid metabolism. Scientific research reveals that a variety of genes are involved in maintaining methionine/homocysteine balance (methylation potential). Genetic polymorphisms in these important genes influence your methylation potential. Individual methylation is monitored using homocysteine levels. Important SNPs (single nucleotide polymorphisms) are included to evaluate your ability to methylate toxins so they can more readily be removed from the body.
The Methyl Detox Profile expands on MTHFR genotyping, giving you a more complete picture of your body’s detoxification abilities. The Methyl Detox profile includes smart commentaries, detailing recommended nutrients based on your genetics.
Who may benefit from this test?
- • Cardiovascular Diseases such as Hypertension, coronary artery disease, stroke 4-10
- • Neurological Disorders such as depression, dementia, Alzheimer’s disease, ADD/ADHD, autism spectrum disorder, chronic fatigue syndrome, migraine, insomnia 7, 10-17
- • Metabolic Conditions such as metabolic syndrome, diabetes, kidney diseases, reduced ability to metabolize medications, multiple chemical sensitivity 10, 18-21
- • Musculoskeletal Disorders such as osteoporosis (in patients with Parkinson’s disease) 10, 22
- • Eye Diseases such as macular degeneration 23, 24
- • Cancer such as colorectal, breast 1, 10, 25
Test results include smart commentaries created by clinicians and scientists. Smart Commentaries include personalized recommendations for diet and nutritional supplementation.
About our lab
Cell Science Systems, Corp. is a specialty clinical laboratory that develops and performs laboratory testing in immunology and cell bioligy supporting the personalized treatment and prevention of chronic disease. Cell Science Systems, Corp. operates a CLIA certified laboratory and is an FDA inspected and registered, cGMP medical device manufacturer meeting ISO EN13485 2012 standards. 3, 17-19
Committed to quality
Cell Science Systems fulfills high quality standards in accordance with state, federal and international regulations.
CE Marked. TUV Certified and safety monitored
Supported by the EU and the State of Brandenburg
ISO 13485:2003 + AC:2012
To view the references or learn more, visit:
The MTHFR gene is essential in the folate metabolism pathway. If the MTHFR gene has no SNP, the body can produce sufficient levels of functioning MTHFR enzyme, which is important for many biochemical processes and pathways in the body to maintain optimal health. A mutation to the MTHFR gene will affect the activity of the resulting enzyme. 5, 6, 10, 26-29
MTR converts homocysteine to methionine using Vitamin B12. Mutations in this gene significantly impact homocysteine metabolism, which increases the risk for a number of chronic conditions.30
COMT is necessary for maintaining the proper balance of neurotransmitters by using SAMe obtained from methionine. Disruption in this pathway can result in various neurological problems.
COMT also plays an important role in a variety of disorders, including estrogen-induced cancers, Parkinson’s disease, depression, hypertension and many others.31-36
Homocysteine is an amino acid – a metabolic intermediate – that is involved in maintaining the methionine cycle. Elevated homocysteine levels are well known risk factors for chronic disease, particularly cardiovascular, diabetes and neurodegenerative.7, 10, 37
cancers, Parkinson’s disease, depression, hypertension and many others.31-36